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bio-availability in toxico- or pharmacokinetics

Ratio of the systemic exposure from extravascular (ev) exposure to that following intravenous (iv) exposure as described by the equation:

F = AevDiv / Biv Dev

where F (fraction of dose absorbed) is a measure of the bioavailability, A and B are the areas under the (plasma) concentration time curve following extravascular and intravenous administration respectively, and Dev and Div are the administered extravascular and intravenous doses.

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  • Walter Lane
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