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extrapolation

Calculation, based on quantitative observations in exposed test species or in vitro test systems, of predicted dose-effect and dose-response relationships for a substance in humans and other biota including interspecies extrapolations and extrapolation to susceptible groups of individuals.

Note: The term may also be used for qualitative information applied to species or conditions that are different from the ones in which the original investigations were carried out.

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  • Walter Lane
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